Model & Strategy

Open Biome is a nonprofit stool bank, expanding safe access to fecal transplants and catalyzing research into the human microbiome. They work with clinicians to make Fecal Microbiota Transplantation (FMT) easier, cheaper, safer and more widely available. They provide hospitals with screened, frozen material ready for clinical use. This service eliminates the time, staff, protocols, and facilities needed to screen and prepare material from new donors for each treatment.

OpenBiome currently utilizes safe access to fecal microbiota transplantation (FMT) for patients suffering from recurrent Clostridium difficile infections. They provide doctors with rigorously screened, ready-to-use stool preparations for use in FMT, and support researchers with a suite of tools to discover new applications of FMT for treating diseases beyond C. difficile.  Using a universal stool banking model, OpenBiome eliminates the practical and financial barriers to providing FMT.

At a Glance
Founded: 2012
Health
Location of work: International
OpenBiome
200 Inner Belt Road
Somerville, MA 02143
Catalyzing research into the microbiome
Meet Mark Smith and James Burgess

While completing his PhD in microbiology at MIT, co-founder and Research Director Mark Smith studied how the good bacteria living in our guts could be transferred through fecal microbiota transplantation (FMT) to cure patients with deadly C. difficile infections.  This academic interest became personal when a close family friend contracted C diff and fought the disease for nearly 2 years.

In 2012, Mark teamed up with co-founder and Executive Director James Burgess to launch OpenBiome and build the public health infrastructure needed to enable FMT for the hundreds of thousands of patients suffering from C diff in this country.  Their vision is also to build OpenBiome as a center for research and inquiry into the role these bacteria play in changing health outcomes for millions of other Americans.

Mark completed his PhD in microbiology at MIT where his research was published in leading journals like Nature, PNAS, and NEJM.

James previously worked as a management consultant at Bain & Company and as a project manager at the Bill & Melinda Gates Foundation.

IMPACT

OpenBiome has significantly expanded access for patients who previously could not find a physician to perform FMT.

Since 2013, OpenBiome has partnered with over 800 medical facilities across all 50 U.S. states and 6 countries to deliver more than 20,000 treatments for recurrent C. difficile.

 

 

A leader in the field of FMT research, OpenBiome is also facilitating 13 clinical trials. Its portfolio includes 49% of all U.S. trials exploring the use of FMT to treat diseases beyond C. difficile.

  • RT @AtlanticLIVE: Why do we look to the microbiome for curing cancer? "Bacteria are like software, allowing us to evolve," says @caredelste…
  • RT @AtlanticLIVE: Is there an ideal microbiome associated with great immunity and responsiveness? Maybe we'll get there. It's definitely go…
  • RT @AtlanticLIVE: At #PeopleVCancer, @JenWargoMD discusses methods for detecting the bacteria that may one day cure cancer: https://t.co/ZC…
  • RT @AtlanticLIVE: .@caredelstein explains that her cousin went into the hospital for a routine surgery and came out with a C-dif infection.…
  • RT @AtlanticLIVE: How does the microbiome help with patient’s receptivity to immunotherapy? @caredelstein of @OpenBiome and @JenWargoMD of…
  • Join us at 1:30 PM ET today for #PeopleVCancer's panel on cancer and the microbiome! You can watch at… https://t.co/7pZLXTQn0O
  • Tune in to #PeopleVCancer today! The session on cancer and the #microbiome begins at 1:30 PM ET - watch at… https://t.co/uR7UdgqtWB
  • How is the microbiome involved in cancer treatment? Learn more at 1:30 PM ET tomorrow (11/14) when our Executive Di… https://t.co/l3VMcgFhRe
  • RT @cduvallet: At first, I was worried that rational donor selection for FMT trials didn't fit with the theme of "microbiome engineering" -…
  • RT @cduvallet: FMT plays an important role in discovery & development, esp for finding avenues with proven causal clinical impact for micro…
  • RT @NinaFinley: The Nexus of Poop and Public Health. We’re living in a microbial world, people! It’s not every day I get to sketch #poop. F…
  • Looking to the microbiome for global health solutions: OpenBiome's Dr. Shrish Budree presents on the gut… https://t.co/WjwT6ZOSwQ
  • RT @CarrollLab: A new Carroll lab paper is out in @JPGNonline, with our clinical collaborator Dr. Ajay Gulati! A fascinating case of recurr…
  • Earlier in August, @OpenBiome shipped its 37,731st treatment. Tonight, we’re celebrating this milestone by attendin… https://t.co/dDQKiGVwoR
  • RT @TamarKahn: Once you get over the ‘ick’ factor this is really cool science: fecal transplants for severely malnourished kids - SA trial…
  • Read more about THRIVE - our #FMT malnutrition study in South Africa - in today's @BDliveSA. Thank you @TamarKahn f… https://t.co/RTy1coIDm2
  • Our global health team is reporting in from Cape Town, South Africa, where we are launching the THRIVE study to loo… https://t.co/vm9jjro3S6
  • Hello from Cape Town! Members of our Global Health team are on a study initiation visit to launch the first FMT cli… https://t.co/GGmEji98lM
  • RT @offbyjuan: Incredible talks at Our Microbes, Our Global Health Symposium. Breathtaking to see the range of applications possible throug…